淫羊藿多糖促进免疫功能的实验研究

中药淫羊藿多糖成分50mg/kg以上剂量连续皮下给药,7天,可显著促进小鼠免疫功能。表现如下:(1)增加脾脏的PFC数,溶血空斑也显著增大。(2)提高血清溶血素水平。(3)增加外周血白细胞数、淋巴细胞及脾有核细胞数,并促进PHA刺激的淋巴细胞转化反应。(4)增强腹腔Mφ吞噬功能。(5)使脾脏重量增加,胸腺减轻。

Experimental Studies on Immunpstimulatary Effects of The Polysaccharides of Epimedium Koreamum Nakai

The immunostimulatary effects of the polysaccharides extracted from Yin yang ho (Epimedium koreamum Nakai ) in mouse at doses of 50-200mg/kg/day for 7 days (S C) were demonstrated as follows: 1 . The number of PFC in mouse spleen was increased, and the size of plaques was enlarged. 2 . The serum level of hemo-lysin antibody from mouse immunized with SRBC was raised. 3 . The number of WBC & lymphocyte in peripheral blood and the nucleated cells in spleen were increased, and percentage of lymphocyte transformation induced by PHA was enhanced. 4 . The pha-gocytic activity of peritoneal macrophage on chicken RBC was stimulated. 5 . The size of spleen was increased and that of thymus was decreased.