| 甲孕酮对人卵巢癌3AO细胞C－erb B－2表达和形态学的影响 |
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| 引用本文： | 丰有吉,金志军,张惜阴,赵凤娣,周先荣,李燕萍.甲孕酮对人卵巢癌3AO细胞C－erb B－2表达和形态学的影响[J].复旦学报(医学版),1994(1). |
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| 作者姓名： | 丰有吉 金志军 张惜阴 赵凤娣 周先荣 李燕萍 |
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| 作者单位： | 上海医科大学妇产科医院妇科 |
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| 摘 要： | 采用流式细胞和电镜技术，检测了甲孕酮处理前后人卵巢癌３ＡＯ细胞Ｃ－ｅｒｂＢ－２表达和形态学改变情况。结果表明甲孕酮可使部分３ＡＯ细胞Ｃ－ｅｒｂＢ－２表达下降；部分３ＡＯ细胞发生形态学改变，提示甲孕酮具有低调部分人卵巢癌３ＡＯ细胞Ｃ－ｅｒｂＢ－２表达和诱导部分３ＡＯ细胞分化的作用。
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| 关 键 词： | 甲孕酮 卵巢癌 C－erbB－2 形态学 |
MEDROXYPROGESTERONE EFFECT ON C-erb B-2 PROTEIN EXPRESSION AND CELL HISTOLOGY IN THE HUMAN OVARIAN 3AO CANCER CELL LINE |
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| Feng Youji,Jin Zhijun, Zhang Xiyin, Zhao Fengdi,Zhou Xianrong, Li Yanping.MEDROXYPROGESTERONE EFFECT ON C-erb B-2 PROTEIN EXPRESSION AND CELL HISTOLOGY IN THE HUMAN OVARIAN 3AO CANCER CELL LINE[J].Fudan University Journal of Medical Sciences,1994(1). |
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| Authors: | Feng Youji Jin Zhijun Zhang Xiyin Zhao Fengdi Zhou Xianrong Li Yanping |
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| Abstract: | C-erb B-2 protein expression and the histological changes after treatment with medroxyprogesterone in human ovarian cancer 3AO line cells were detectedby flow cytometry(indirect fiuoresence)and the electron microscope. The resnltsshowed that most cell histology showed normal changes, and the expressi on of C-erb B-2 protein was low after treatment with medroxyprogesterone. These data suggest that progesterone has effects on cell differentiation and down-regnulation of C-erb B-2 protein expression in the human ovarian 3AO cancer cell-line. |
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| Keywords: | medroxyprogesterone cvarian cancer C-erb B-2 morphology |
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