食管癌原发灶PET-CT氟代脱氧葡萄糖摄取及其与临床病理参数的相关性

目的 从分子影像学角度,探讨治疗前食管癌原发灶PET-CT氟代脱氧葡萄糖(FDG)摄取与病变长度、肿瘤浸润深度、组织分化程度以及淋巴结转移状况的关系.方法 68例食管鳞癌患者术前行FDG PET-CT检查,测定最大标准摄取值(SUVmax),根据术后病理确定其病变长度、浸润深度、分化程度以及淋巴结转移情况.结果 68例食管癌患者肿瘤原发灶的SUVmax为10.7±5.3.不同浸润深度、分化程度及淋巴结转移情况的食管癌SUVmax差异均有统计学意义(均P<0.05).原发灶SUVmax与病变长度、浸润深度、分化程度及淋巴结转移情况均呈正相关(r=0.512,P=0.01;r=0.860,P=0.000;r=0.781,P=0.000;r=0.852,P=0.000).结论 食管癌原发灶SUVmax与病变长度、浸润深度、分化程度均呈正相关,发生淋巴结转移者原发灶的SUVmax高于无淋巴结转移者.

Correlation between PET-CT 18FDG uptake in primary lesions and clinicopathological parameters in esophageal carcinoma patients

Objective To investigate the correlation between 18F-fluorodeoxyglucose (18FDG) uptake of primary lesions during PET-CT (positron emission tomography and computed tomography) examination and clinicopathological parameters such as the tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status in the patients with esophageal carcinoma. Methods From June 2004 to November 2006, 68 operable esophageal carcinoma patients were enrolled into this study, and all had a whole body 18FDG PET-CT scan before operation. The maximum standardized uptake value (SUVmax) of the primary lesions was measured. The tumor length, depth of invasion, differentiation of the primary lesions and lymph node metastasis status were determined by postoperative pathological examination. The correlation between the standardized uptake value (SUV) of primary lesions and the above mentioned clinicopathological parameters was analyzed. Results The overall length of primary lesion was positively correlated with SUVmax (r = 0. 512, P = 0.01 ). Depth of invasion was also positively correlated with SUVmax (r = 0. 860, P = 0. 000 ). There was a statistically significant difference in SUVmax between poorly differentiated group and moderately or well differentiated group ( r = 0.781, P = 0. 000), and also between the groups with or without lymph node metastasis ( r = 0. 852, P = 0. 000). Conclusion The tumor length, depth of invasion and differentiation of the primary lesions of the esophageal carcinoma are all positively correlated with maximum standardized uptake value of 18FDG. The more poorly differentiated lesions show a higher 18FDG maximum standardized uptake value. The lesions with lymph node metastasis have also a significantly higher 18FDG maximum standardized uptake value than those without lymph node metastases.