| 围体外循环期红细胞膜流动性和脂质过氧化损伤的临床研究 |
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| 引用本文： | 阎玉生,龙国粹,李中学,程群立,冯树生,李斌.围体外循环期红细胞膜流动性和脂质过氧化损伤的临床研究[J].中华胸心血管外科杂志,1994(2). |
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| 作者姓名： | 阎玉生 龙国粹 李中学 程群立 冯树生 李斌 |
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| 作者单位： | 广州珠江医院心胸外科 |
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| 摘 要： | ３３例心脏直视手术病人围体外循环期红细胞膜流动性和脂质过氧化损伤的临床研究表明：体外循环（ＣＰＢ）造成了未破裂、溶血的红细胞膜流动性损伤，损伤高峰期在ＣＰＢ后６～８ｈ，脂质过氧化是其损伤的主要原因。ＣＰＢ中活力升高的超氧化物歧化酶（ＳＯＤ）对红细胞膜流动性的保护能力不足，血浆游离血红蛋白的变化不能反映完整红细胞的受损情况，和膜流动性之间无相关关系。
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| 关 键 词： | 体外循环，红细胞，膜流动性，脂质过氧化 |
A Clinical Research on the Fluidity of Erythrocyte Membrane and the Injury of Lipid Peroxidation in the Peri-Cardiopulmonary Bypass |
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| Yu-sheng Yan,Guo-chui Long,Zong-xue Li,et al..A Clinical Research on the Fluidity of Erythrocyte Membrane and the Injury of Lipid Peroxidation in the Peri-Cardiopulmonary Bypass[J].Chinese Journal of Thoracic and Cardiovascular Surgery,1994(2). |
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| Authors: | Yu-sheng Yan Guo-chui Long Zong-xue Li |
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| Abstract: | The fluidity of erythrocyte membrane and its injury by lipid peroxidation were surveyed in peri-cardiopulmonary bypass.The results gained from 33 cases of open heart surgery indicated that the membrane fluidity of integrated erythrocyte was injuried by cardiopulmonary bypass(CPB).The most serious injury appeared in 6-8 hours post-CPB and lipid peroxidation was the major cause leading to the injury.The activity of superoxide dismutase (SOD)was increased during and after CPB but was not high enough to protect the membrane fluidity.No relationship was found between plasma hemoglobin(P.Hb)and membrane fluidity.So,the value of P.Hb can not be the experession of the extent of injury of membrane fluidity. |
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| Keywords: | Cardiopulmonary bypass(CPB) Erythrocyte Membrane fluidity Lipid peroxidation |
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