The effect of imipramine administered before and during pregnancy on litter size in the rat |
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| Authors: | G. Singer I. R. Coyle |
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| Affiliation: | (1) Department of Psychology, La Trobe University, 3083 Bundoora, Victoria, Australia |
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| Abstract: | Previous studies have suggested that anti-depressants administered during pregnancy result in an increase in foetal and neonatal morbidity. The present study examined the effects of the anti-depressant imipramine administered before and during pregnancy on litter size in the rat. Imipramine was found to cause a significant reduction in litter size with doses that are used therapeutically.The authors wish to express their thanks to Ciba-Geigy (Australia) Ltd. for supplying imipramine. |
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| Keywords: | Imipramine Pregnancy Litter Size Teratogenicity |
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