| Uterine Natural Killer Cells： Their Choices, Their Missions |
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| 引用本文： | Zhang J,Croy BA,Tian Z. Uterine Natural Killer Cells： Their Choices, Their Missions[J]. Cellular & molecular immunology, 2005, 2(2): 123-129 |
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| 作者姓名： | Zhang J Croy BA Tian Z |
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| 作者单位： | Jianhong Zhang~(1,2) B Anne Croy~3 Zhigang Tian(1,4) ~1School of Life Sciences,University of Science and Technology of China,Hefei,Anhui 230027,China;~2Center of Laboratory Animals,Shanxi Medical University,Taiyuan,Shanxi 300001,China;~3Department of Anatomy and Cell Biology,Queen's University,Kingston,Ontario,K7L 3N6,Canada; |
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| 摘 要： | Uterine natural killer(uNK)cells,sharing many characters with peripheral blood natural killer(pNK)cells,are amajor uterine lymphocyte population at early gestational stages during normal pregnancy in placental mammals.The functions of uNK cells include cytokine production and cytotoxcity that are regulated by signals throughactivating and inhibitory receptors.UNK cells differ from pNK cells however and contribute to the structuralchanges that accompany the differentiation of the maternal-fetal interface.Immunological mechanisms mustprovide a balanced environment for uNK cell proliferation,differentiation and activation through intricatesignaling pathways.An improved knowledge of mechanisms regulating uNK cells development and the cytokinenetwork at the maternal-fetal interface of mice and humans might be useful to harness the power of these cells formaintenance of pregnancy.Cellular & Molecular Immunology.2005;2(2):123-129.
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| 关 键 词： | 自然杀伤细胞 细胞免疫 分子免疫 淋巴细胞 |
Uterine natural killer cells: their choices, their missions |
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| Zhang Jianhong,Croy B Anne,Tian Zhigang. Uterine natural killer cells: their choices, their missions[J]. Cellular & molecular immunology, 2005, 2(2): 123-129 |
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| Authors: | Zhang Jianhong Croy B Anne Tian Zhigang |
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| Affiliation: | School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China. |
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| Abstract: | Uterine natural killer(uNK)cells,sharing many characters with peripheral blood natural killer(pNK)cells,are a major uterine lymphocyte population at early gestational stages during normal pregnancy in placental mammals. The functions of uNK cells include cytokine production and cytotoxcity that are regulated by signals through activating and inhibitory receptors.UNK cells differ from pNK cells however and contribute to the structural changes that accompany the differentiation of the maternal-fetal interface.Immunological mechanisms must provide a balanced environment for uNK cell proliferation,differentiation and activation through intricate signaling pathways.An improved knowledge of mechanisms regulating uNK cells development and the cytokine network at the maternal-fetal interface of mice and humans might be useful to harness the power of these cells for maintenance of pregnancy.Cellular & Molecular Immunology.2005;2(2):123-129. |
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| Keywords: | uNK cell pregnancy lymphocyte differentiation lymphocyte activation cytokine |
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