Novel geometry type of nanocarriers mitigated the phagocytosis for drug delivery |
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| Authors: | Shuian-Yin Lin Wei-Hsin Hsu Jem-Mau LoHsieh-Chih Tsai Ging-Ho Hsiue |
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| Affiliation: | a Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 300 Taiwan, ROCb Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, 300 Taiwan, ROCc Graduate Institute of Engineering, National Taiwan University of Science and Technology, 106 Taipei, Taiwand Department of Chemical Engineering/R&D Center for Membrane Technology, Chung Yuan University, Chung Li, 320 Taiwan, ROC |
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| Abstract: | Target geometry for mitigating phagocytosis has garnered considerable attention recently in the drug delivery field. This study examined nanoparticles (NPs) with same volume but different shapes, namely, spherical NPs (SNPs) and hexagonal nanoprisms (HNPs), and analyzed their behaviors in vitro and in vivo. These NPs were constructed with a multifunctional block copolymer component, mPEG-b-P(HEMA-co-histidine-PLA). Geometry of SNPs and HNPs was controlled by adjusting copolymer properties and particle size was controlled by adjusting formulation parameters. Nanoparticle morphology had no effect in mitigating phagocytosis when NP size was 70 nm; however, morphology had a significant effect when NP size was 120 nm. The radioactivity-time curves for 99mTc-labeled NPs, fitted by the two-compartment pharmacokinetic model, show that the prolonged plasma distribution half-life of HNPs is indicative in the bloodstream. The in vitro and in vivo studies reveal that dual stealth characteristics, pegylation and hexagonal prism structure, of nanocarriers can be adopted in clinical application for safe and efficient delivery of cancer therapy. |
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| Keywords: | Hexagonal nanoparticles Drug delivery Phagocytosis Pharmacokinetic |
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