Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates |
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Authors: | In-Hyun LeeSukyung An Mi Kyung YuHo-Keun Kwon Sin-Hyeog ImSangyong Jon |
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Institution: | Cell Dynamics Research Center, School of Life Sciences, Gwang ju Institute of Science and Technology, 261 Cheomdan-gwagiro, Buk-gu, Gwang ju 500-712, Republic of Korea |
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Abstract: | We reported an innovative, targeted chemoimmuno drug-delivery system. Although chemoimmunotherapy, as an alternative to or in combination with conventional therapeutic systems, has been in the forefront of recent oncological research, as presently configured, such systems face several major obstacles for efficient clinical application. Here, we establish a novel nano-platform for effective chemoimmunotherapy designed to overcome the drawbacks of conventional cancer therapies, describing a delivery system based on a dendrimer and a single-strand DNA-A9 PSMA (prostate-specific membrane antigen) RNA aptamer hybrid. Employing these vehicles, we demonstrate the promising possibility of this chemoimmuno therapeutic system against prostate cancer in in vivo and in vitro models. |
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Keywords: | PSMA aptamer Dendrimers Doxorubicin Targeted chemoimmunotherapy Cancer therapy |
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