Diabetic retinopathy is associated with subclinical atherosclerosis in newly diagnosed type 2 diabetes mellitus |
| |
Authors: | Son Jang-Won Jang Eun-Hee Kim Mee-Kyoung Kim In Tae Roh Young Jung Baek Ki-Hyun Song Ki-Ho Yoon Kun-Ho Cha Bong-Yun Lee Kwang-Woo Son Ho-Young Kwon Hyuk-Sang |
| |
Institution: | a Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Mary's Hospital, The Catholic University of Korea, # 62, Yeoido-dong, Yeoung deungpo-gu, Seoul 150-713, Republic of Korea b Department of Ophthalmology and Visual Science, The Catholic University of Korea, St. Mary's Hospital, Seoul, Republic of Korea |
| |
Abstract: | AimsWe aimed to evaluate the association between diabetic microangiopathy and subclinical atherosclerosis as a marker of cardiovascular disease (CVD) risk in patients with newly diagnosed type 2 diabetes.MethodsA total of 142 newly diagnosed type 2 diabetics who were free from CVD underwent evaluation of diabetic microangiopathy. Subclinical atherosclerosis was assessed by measuring carotid intima-media thickness (IMT), and the 10-year absolute risk of CVD was estimated using the UK Prospective Diabetes Study (UKPDS) Risk Engine.ResultsSubclinical atherosclerosis was found in 27 subjects (19.0%). The rates of hypertension and diabetic retinopathy were significantly higher among patients with subclinical atherosclerosis. The UKPDS 10-year risk for CVD was significantly increased in subjects with subclinical atherosclerosis. Old age, hypertension and the presence of diabetic retinopathy showed a significant association to subclinical atherosclerosis after further adjustments for gender, body mass index, smoking status, HbA1c, HDL cholesterol, LDL cholesterol and the presence of diabetic nephropathy.ConclusionsThis study shows that diabetic retinopathy is an independent risk marker for subclinical atherosclerosis in patients with newly diagnosed type 2 diabetes. We suggest that a diagnosis of diabetic retinopathy may warrant a more careful cardiovascular assessment even in the early stages of diabetes. |
| |
Keywords: | Diabetic retinopathy Carotid intima-media thickness Atherosclerosis |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|