Skeletal muscle determinants of maximum aerobic power in man

Summary The interrelationship between whole body maximum O₂ uptake capacity ( O_{2 max}), skeletal muscle respiratory capacity, and muscle fiber type were examined in 20 physically active men. The capacity of homogenates of vastus lateralis muscle biopsy specimes to oxidize pyruvate was significantly related to O_{2 max} (r=0.81). Correlations of 0.75 and 0.74 were found between % slow twitch fibers (%ST) and O_{2 max}, and between % ST fibers and muscle respiratory capacity, respectively (P<0.01). Multiple correlation analysis (R=0.85) indicated that 72% (R ²=0.72) of the variance in CO_{2 max} could be accounted for by the combined effect of muscle respiratory capacity and the % ST fibers. When the % ST fibers was correlated with O_{2 max}, with the effect of respiratory capacity statistically removed, the relationship became insignificant (r=0.38). These data suggest that muscle respiratory capacity plays an important role in determining O_{2 max}, and that the relationship between % ST fibers and O_{2 max} is due primarily to the high oxidative capacity of this muscle fiber type.This research was supported by NIH grant (HL 20408-02)