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Whole-genome sequence analysis of a Korean G11P[25] rotavirus strain identifies several porcine-human reassortant events |
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| Authors: | Van Thai Than Jong-Hwa Park In Sik Chung Jong Bum Kim Wonyong Kim |
| Institution: | 1. Department of Microbiology and Research Center for Medical Sciences, Chung-Ang University College of Medicine, Seoul, South Korea 2. Department of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University, Suwon, South Korea 3. Functional Biomaterial Division, National Academy of Agricultural Science, The Rural Development Administration, Suwon, South Korea |
| Abstract: | A rare rotavirus, RVA/Human-wt/KOR/CAU12-2/2012/G11P25], was isolated from a 16-year-old female with fever and diarrhea during the 2012 rotavirus surveillance in South Korea using a cell culture system, and its full genome sequence was determined and analyzed. Strain CAU12-2 exhibited a G11-P25]-I12-R1-C1-M1-A1-N1-T1-E1-H1 genotype constellation. Phylogenetic analysis of this strain revealed that it is a human-porcine reassortant of two distant relatives of the G11 strains circulating in the world. The VP7 and VP4 genes are most closely related to those of human G11P25] viruses (Dhaka6, KTM368, and N-38 strains) identified in South Asia, whereas the VP1 gene originated from a porcine G11P7] virus (YM strain) that was identified in South America. The VP6 gene was found to belong to the new genotype I12. This study indicates that the G11-P25]-I12 genotype was introduced into the South Korean population by interspecies transmissions of human and animal rotaviruses, followed by multiple reassortment events. |
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