| 硒钴对培养鼠心肌细胞电生理的影响 |
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| 引用本文： | 段耀奎,曹文华,王福顺,李金国,宋希俊. 硒钴对培养鼠心肌细胞电生理的影响[J]. 微量元素与健康研究, 2003, 20(3): 1-2,5 |
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| 作者姓名： | 段耀奎 曹文华 王福顺 李金国 宋希俊 |
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| 作者单位： | 1. 山东泰山医学院生理教研室,泰安,271000
2. 泰山医学院附属医院,泰安,271000 |
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| 基金项目： | 山东省教育厅资助课题(J97K10 ) |
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| 摘 要： | 目的 :进一步研究微量元素硒 (Se)钴 (Co)对心肌细胞的协同性影响。方法 :用细胞内微电极技术分别测定了正常对照、高Co、高Se伴高Co条件下培养的大鼠心肌细胞生物电活动的变化。结果 :高Co状态下培养的心肌细胞 ,其RP、APA降低 ,APD50 缩短 ;而高Co伴高Se条件下培养的心肌细胞 ,RP、APA、APD50 与对照组相比差异无显著性意义。提示 :高Co对培养的心肌细胞有损害作用 ,补Se可以对抗高Co对心肌细胞产生的这种损害
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| 关 键 词： | 硒 钴 心肌细胞 电生理 |
| 文章编号： | 1005-5320(2003)03-0001-02 |
Synergic Effect of Se and Co on the Electrophysiological Properties of Myocardial Cells of the rat |
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| DUAN Yao-kui,CAO Wen-hua,WANG Fu-shun,LI Jin-guo,SONG Xi-jun. Synergic Effect of Se and Co on the Electrophysiological Properties of Myocardial Cells of the rat[J]. Studies of Trace Elements and Health, 2003, 20(3): 1-2,5 |
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| Authors: | DUAN Yao-kui CAO Wen-hua WANG Fu-shun LI Jin-guo SONG Xi-jun |
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| Abstract: | Objective:To explore the synergic effect of Se and Co on the electrophysiological properties of myocardial cells. Methods: Intracellular microelectrode technique was used to study the electrophysiological changes of the myocardial cells cultured at the state of the different Se and Co concentration. Results: It has been confirmed that Co lowered the RP ? APA and shorted the APD 50 of the cultured cell. However, when Se was added to the experimental system, these electrophysiological parameters have no significantly changes than the control. Conclusions: It suggested that Co injury the cultured myocardial cells, and Se prevent these cells from the injury. |
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| Keywords: | Selenium Cobalt Myocardial cell Electrophysiology |
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