| ~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice |
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| 引用本文： | 陈志南,刘彦仿,隋延仿,付承华,徐力青. ~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J]. 中国人民解放军军医大学学报, 1993, 0(2) |
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| 作者姓名： | 陈志南 刘彦仿 隋延仿 付承华 徐力青 |
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| 作者单位： | Department of Pathology Fourth Military Medical University，Xi'an 710032，Department of Pathology，Fourth Military Medical University，Xi'an 710032，Department of Pathology，Fourth Military Medical University，Xi'an 710032，Department of Pathology，Fourth Military Medical University，Xi'an 710032，Department of Pathology，Fourth Military Medical University，Xi'an 710032 |
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| 摘 要： | Anti-hepatoma monoclonal antibodies HAb8,HAb18 IgG and HAb18 F(ab')_2were labelled with[~(131)I]according to chloramine T method.The labelling rate andradioactivity were 51% and 9.58×10~4Bq/mg,respectively.After administration of the[~(131)I]-labelled conjugates through mouse tail vein,hepatoma xenografts were clearly im-aged,Localization index was 2.15,3.09,and 6.99 for HAb8,HAb18 IgG and HAb18F(ab')_2,respectively.A total of 16 hepatoma-bearing nude mice(SMMU-LTNM)were di-vided into 4 groups.When xenografts reached 0.3cm in diameter,the treatment was be-gun by injection of the[~(131)I]-conjugates through mouse tail vein.After 2 weeks of treat-ment,obvious inhibitory or killing effects on the xenografts were found.The tu-mor-bearing mice were killed during the period from 14 to 21d after treatment.Xenografts as well as other organs were sampled and viewed under light microscope ac-cording to routine procedure.The vital organs,such as heart,liver,spleen,lung,kidneyand brain showed no pathological lesions.In hepatoma xenografts,some tumor cellmembranes were found,with obscure cytoplasmic structure and increased eosinophilia,representing necrotic alterations.
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~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice |
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| Chen Zhinan Liu Yanfang Sui Yanfang Fu Chenghua Xu Liqing. ~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J]. Journal of Medical Colleges of PLA(China), 1993, 0(2) |
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| Authors: | Chen Zhinan Liu Yanfang Sui Yanfang Fu Chenghua Xu Liqing |
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| Affiliation: | Chen Zhinan Liu Yanfang Sui Yanfang Fu Chenghua Xu Liqing Department of Pathology,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | |
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| Keywords: | hepatoma experimental antibodies monoclonal isotope labelling targeting therapy mice nude |
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