肝硬化患者QT离散度的改变

目的观察肝硬化患者体表心电图QTd改变及其与肝功能的关系。方法70例肝硬化患者,年龄（51.8±10.0）岁,按Child-Pugh肝功能分级标准分为Child A组（n=24）,Child B组（n=24）和Child C组（n=22）。30例健康体检者作对照组,年龄（48.4±9.3）岁。记录12导联同步心电图,测量QT间期,根据心率计算校正的QT间期（QTc）;QTcd等于最大QTc减最小QTc。比较各组QTcd均值及QTcd延长（≥50ms）患者的比例。结果对照组、Child A组、Child B组、Child C组QTcd（ms）分别为37.±54.9,38.9±4.6,46.7±7.0,53.6±8.0;对照组和Child A组无QTcd≥50ms者,Child B组和Child C组QTcd延长者分别为25.0%和54.5%。对照组和Child A组比较无QTcd明显差异（P〉0.05）,Child B组和Child C组皆较对照组和ChildA组增大（均P〈0.01）;Child C组较之ChildB组QTcd进一步加大（P〈0.01）,QTcd延长者比例增加（P〈0.05）。结论肝硬化患者QTd增大,与肝功能损害严重程度相一致。

The change of QT dispersion in patients with liver cirrhosis

Objective To assess the change of QT dispersion （QTd） in patients with liver cirrhosis, and the relationship between QTd and the Liver function. Methods 70 patients （51.8 ±10.0 years old） with liver cirrhosis were divided into A（ n=24 ）, B（n=24） and C （n=22）group according to the Child-Pugh score, and the rate-corrected QT division （QTcd） was calculated. 30 healthy （48.4 ± 9.3 years old） were regarded as the control group. Results The QTcd of group control, Child A ,Child B and Child C was 37.5 ± 4.9,38.9 ± 4.6,46.7 ± 7.0and 53.6 ± 8.0 respectively. No QTcd≥ 50 ms in group control and group Child A. The lengthen QTcd in group Child Band Child C was 25.0%和54.5%. There was no difference between group A and control （P〉0.05）. QTcd in Child C group and Child B group was longer than either in Child A and Control （P〈0.01）.The rate of QTcd prolonged patients in Child B group was lower than that in Child C group （P〈0.05）. Conclusion QTd tends to increase in patients with cirrhosis, and the divided degree of QT interval is coincidence with the damage of liver function.