迟发型维生素K缺乏症46例临床分析与预防探讨

目的探讨迟发型维生素K缺乏症临床特征与预防措施。方法回顾性分析46例迟发型维生素K缺乏症的临床表现及辅助检查。结果46例迟型维生素K缺乏致颅内出血36例,发生率78.3%。本组病例治愈32例,治愈率69.6%,死亡3例,病死率6.5%,病情好转自动出院9例(19.6%),无效放弃治疗2例(4.3%)。结论迟发型维生素K缺乏症以自发性颅内出血为特征。新生儿从出生至生后3个月定期小剂量补充维生素K1可预防本病发生。

Clinical Analysis of 46 Cases of Delayed Vitamin K Deficiency and Prevention Measures

Objective To explore the clinical feature and preventive measures of delayed vitamin K deficiency.Methods The clinical data and assistant examination materials of 46 cases with delayed vitamin K deficiency were analyzed retrospectively.Results The intracranial hemorrhage induced by vitamin K deficiency was found in 36 cases and the incidence rate was 78.3% (36/46).Among total 46 cases,32 cases were cured with a cure rate of 69.6%;3 cases died with a mortality rate of 6.5%;9 cases were improved with a rate of 19.6%;2 cases gave up treatment which accounts for 4.3%.Conclusions The idiopathetic intracranial hemorrhage is the feature of delayed vitamin K deficiency.The periodical administration of supplementary vitamin K1 at a small dose can prevent this disease in all infants from birth to 3 months.