| 仙灵骨葆对切除卵巢骨质疏松模型大鼠腰椎骨抗压生物力学性能的影响 |
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| 引用本文： | 朱太咏 石印玉. 仙灵骨葆对切除卵巢骨质疏松模型大鼠腰椎骨抗压生物力学性能的影响[J]. 中医正骨, 2000, 12(9): 3-5 |
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| 作者姓名： | 朱太咏 石印玉 |
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| 作者单位： | 河南省洛阳正骨医院正骨研究所!471002(朱太咏,王健智),上海中医药大学附属曙光医院(石印玉),上海市中医药研究院骨伤科研究所(张弋,沈培芝,赵咏芳,徐宁,史万忠) |
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| 摘 要： | 为探讨仙灵骨葆对大鼠去卵巢骨质疏松模型松质骨生物力学性能的影响,将４０只１０月龄Ｗｉｓｔａｒ月龄Ｗｉｓｔａｒ雌性大鼠随机分为正常对照组,模型对照组,仙灵骨葆组和倍美力组,每组１０只,正常对照组做假手术,其余３组做卵巢切除术,术后３个月开始给药,连续用药满９０天,处死,取出第３腰椎,测定其骨量并进行压应力测试与分析。结果显示,仙灵骨葆能明显增加骨质疏松大鼠腰椎骨的整体骨量,改善其生物力学抗压性能。
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| 关 键 词： | 骨质疏松症 中医药疗法 仙灵骨葆 药效学 |
EFFECT OF "XIANLING GUBAO" ON BIOMECHENICAL PROPERTIES OF LUMBOVERTEBRAL BONE IN OVARIECTOMIZED RAT |
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| Zhu Taiyong,Shi Yinyu,Wang Jianzhi Luoyang Orthopedic Institute of Henan Province,Luoyang. EFFECT OF "XIANLING GUBAO" ON BIOMECHENICAL PROPERTIES OF LUMBOVERTEBRAL BONE IN OVARIECTOMIZED RAT[J]. The Journal of Traditional Chinese Orthopedics and Traumatology, 2000, 12(9): 3-5 |
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| Authors: | Zhu Taiyong Shi Yinyu Wang Jianzhi Luoyang Orthopedic Institute of Henan Province Luoyang |
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| Abstract: | In order to explore the effect of "Xianling Gubao" on biomechanical performances of the cancellous bone in ovariectomized rat, 40 Whistar female rats (aged 10 months) were divided randomly into 4 groups: the normal, modelled, "Xianling Gubao" treated and Premarin treated, 10 in each group. The normal group was only shamly operated and the other three were ovariectomized. Three months later postoperatively, the rats were given medicines continuously for 90 days and then killed, the third lumbar vertebra taken out and the whole bone quantity and biomechanical properties determined. The results showed that "Xianling Gubao" could significantly increase the whole bone quantity and improve the biomechanical properties of the lumbovertebral bone in osteoporotic rats. |
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| Keywords: | osteoporosis/TCM therapy Xianling Gubao / therapeutic application Migu Jiaonang/pharmacodynamics biomechanics/bone bone mass experimental study |
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