A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy |
| |
| Authors: | S Matsumoto S Goto A Hirano |
| |
| Institution: | (1) Bluestone Laboratory of the Division of Neuropathology, Montefiore Medical Center, 111 East 210th Street, 10467 Bronx, NY, USA;(2) Present address: Department of Neurology, Kitano Hospital and Neurological Center, Osaka, Japan;(3) Present address: Neurophysiologische Abteilung, Max-Planck-Institut für Hirnforschung, Frankfurt a. M., Federal Republic of Germany |
| |
| Abstract: | Summary Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called  striosomes . In addition, a number of typical woolly fibers were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive woolly fibers appcarance was less well recognizable in the GPe from all the PSP patients examined. |
| |
| Keywords: | Met-Enkephalin Alzheimer's disease Progressive supranuclear palsy Striatum Globus pallidus |
| 本文献已被 SpringerLink 等数据库收录！ |
|
