| 中国五个民族人群样本中酒精代谢相关酶基因多态型分布比较 |
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| 引用本文： | 曹西蓉,吴德生. 中国五个民族人群样本中酒精代谢相关酶基因多态型分布比较[J]. 卫生研究, 2002, 31(3): 156-159 |
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| 作者姓名： | 曹西蓉 吴德生 |
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| 作者单位： | 四川大学华西公共卫生学院,成都,610041 |
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| 基金项目： | 四川省计划生育委员会基金资助 (No .98- 4 - 1 ) |
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| 摘 要： | 采用聚合酶链式反应 限制性片段长度多态性 (PCR RFLP)方法测定酒精脱氢酶 2 (ADH2 )和乙醛脱氢酶 2 (ALDH2 )的基因型 ,以获得ADH2、ALDH2基因多态型在中国汉、回、蒙古、维吾尔、白五个民族正常人群样本中的分布并对其进行比较。结果显示 :(1)五民族中均为杂合型ADH2与纯合型ALDH2占优势 ;(2 )ADH2、ALDH2基因型在五民族的分布间存在一定差异
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| 关 键 词： | 酒精脱氢酶2 乙醛脱氢酶2 民族 基因多态性 易感基因型 |
| 文章编号： | 1000-8020(2002)03-0156-04 |
| 修稿时间： | 2001-09-03 |
Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities |
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| Cao Xirong,Wu Desheng School of Public Health,West China Medical Center of Sichuan University,Chengdu ,China. Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities[J]. Journal of hygiene research, 2002, 31(3): 156-159 |
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| Authors: | Cao Xirong Wu Desheng School of Public Health West China Medical Center of Sichuan University Chengdu China |
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| Affiliation: | School of Public Health, West China Medical Center of Sichuan University, Chengdu 610041, China. |
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| Abstract: | Genotypes of alcohol dehydrogenase 2(ADH2) and aldehyde dehydrogenase 2(ALDH2) were detected by using polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in order to acquire and compare the distributions of polymorphisms about ADH2 and ALDH2 in five Chinese nationalities. The results were as follows: (1) Heterozygous genotype of ADH2 and homozygous genotype of ALDH2 are the two dominant ones in all the five nationalities. (2) The distributions of the two genes 'polymorphisms have certain differences among some nationalities. |
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| Keywords: | alcohol dehydrogenase 2 aldehyde dehydrogenase 2 nationality gene polymorphism susceptible genotype |
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