仙鹿消癖胶囊对性激素及下丘脑DA、MAO含量的影响

目的:观察仙鹿消癖胶囊对实验性乳腺增生小鼠的作用及作用机制。方法:采用苯甲酸雌二醇腹腔注射复制乳腺增生模型,观察仙鹿消癖胶囊对乳腺增生小鼠血清E2、P含量的变化及下丘脑神经递质DA、MAO含量的影响。结果:仙鹿消癖胶囊中、高剂量组能降低E2含量,升高P含量,上调下丘脑神经递质DA含量,抑制MAO的含量。结论:仙鹿消癖胶囊通过影响乳腺增生小鼠血清E2、P含量及下丘脑DA、MAO含量而从整体上调整下丘脑-垂体-卵巢轴,治疗乳腺增生。

Effect of Xianlu Xiaopi Capsules on the Mammary Gland Hyperplasia in Mmice Sex Hormones and Hypothalamic DA and MAO Content

Objective：To observe the effect of Xianlu Xiaopi capsules on cyclomastopathy in rats and its mechanism. Meth- ods All unpregnancy female Wistar rats were randomly divided into blank control group （ group 1 ）, model group （ group 2 ）, tamoxifen group （ group 3 ）, and high - dose, mid - close and low - dose Shugantongluo Formula group. The rat model of cyclomastopathy was established by injecting benzoate estradiol and progestogen intramuscularly for 30 days. The histo- morphological changes of mmmnmy glands, uterus and ovary, and the quantity and diameter of mammary lobule and alve- olus were observed. The serum levels of estradiol （E2 ）, progesterone （P）, Head issuing grave neurotransmitter dopamine （DA） , Monoamine oxidase （ MAO ） the influence of the content in mammary glanas were detected. Results：In high group of Xianlu Xiaopi capsules, the serum E2 level was decreased with a significant difference. The level of P was increased with a significant difference compared with model group. Raise head issueing grave neurotransmitter DA content, inhibit the content of MAO . Conclusion：Xianlu Xiaopi capsules have a therapeutic effect on cyclomastopathy in rats through af- fecting mammary gland hyperplasia mice Serum E2, P content and head issueing grave DA, MAO content and from the whole adjustment hypothalamus - pituitary - adrenal axis ovarian, treatment of mammary gland hyperplasia.