双参宁心胶囊对心导管介入血栓法制备小型猪心肌缺血模型的影响

目的研究自体血栓介入法中国实验小型猪心肌缺血模型的制备，并观察双参宁心胶囊抗心肌缺血作用。方法采用心导管介入技术，经颈总动脉在左冠状动脉前降支内置入导引导管，注入自体血栓，制备中国实验小型猪心肌缺血模型，观察双参宁心胶囊对冠状动脉栓塞、30点体表心电图、定量组织学等一系列综合评价心肌缺血模型指标的影响。结果造模6天后，模型动物冠状动脉前降支基本栓塞，体表心电图ST段抬高的幅度和点数均增加；给药6天后，双参宁心胶囊可明显使自体血栓造成的小型猪冠状动脉前降支栓塞再通，减轻心肌缺血程度和心肌缺血范围。结论本实验首次应用心导管介入血栓法成功制备中国实验小型猪心肌缺血模型，双参宁心胶囊具有抗心肌缺血作用。

Effects of Shuangshen Ningxin Capsule on Mini-porcine Myocardial Ischemia Model Induced by Thrombosis via Cardiac Catheterization Intervention

ObjectiveTo investigate the establishment of mini-porcine myocardial ischemia (MI) model induced by thrombosis via cardiac catheterization intervention, and observe the anti-MI action of Shuangshen Ningxin Capsule (SNC). MethodsMI model of Chinese mini-porcine was established by injection of self-thrombus in left anterior descending coronary artery (LAD) with guiding catheter through carotid artery. The effect of SNC on MI was evaluated comprehensively by analyzing the parameters as coronary embolism, 30 dots surface mapping electrocardiogram and quantitative histology, etc. ResultsLAD in the model animals was basically embolized 6 days after modeling, showing increase of amplitude and dot of ST segment elevation. After being administered with SNC for 6 days, the self-thrombus blocked LAD was recanalized and the degree and extent of MI reduced. ConclusionIt is the first time to successfully establish MI model of Chinese mini-procine by thrombosis via cardiac catheterization intervention. SNC has anti-MI effect.