| 萘普生钠片溶出度测定及体内外相关性评价 |
| |
| 引用本文： | 乐健,刘茜,石劲敏,陈桂良.萘普生钠片溶出度测定及体内外相关性评价[J].药学实践杂志,2008,26(3):211-213. |
| |
| 作者姓名： | 乐健 刘茜 石劲敏 陈桂良 |
| |
| 作者单位： | 上海市食品药品检验所,上海,201203 |
| |
| 摘 要： | 目的:进行萘普生钠片体外溶出度的测定及体内外相关性评价.方法:按USP29版萘普生钠片溶出度测定法测定萘普生钠片体外溶出度,用HPLC法测定萘普生钠片在人体内的血药浓度,并用BAPP2.0程序进行拟合.结果:以体内吸收分数(F)对体外累积溶出率(X)进行线性回归,得方程F=0.330 3X 0.699 8(r=0.991 5),体内吸收分数与体外累积溶出率具有良好的相关性.结论:USP29版萘普生钠片的溶出度方法合理,可以较好反映体内吸收情况.
|
| 关 键 词： | 萘普生钠片 体外溶出度 体内外相关性 萘普生钠 溶出度测定法 体内外 相关性评价 drug evaluation tablets sodium naproxen 情况 体内吸收 度方法 方程 线性回归 溶出率 吸收分数 结果 拟合 程序 血药浓度 |
| 文章编号： | 1006-0111(2008)03-0211-03 |
| 收稿时间： | 2007/7/24 0:00:00 |
| 修稿时间： | 2007年7月24日 |
Dissolution of naproxen sodium tablets and evaluation of in vitro-in vivo correlation about this drug |
| |
| LE Jian,LIU Qian,SHI Jin-min and CHEN Gui-liang.Dissolution of naproxen sodium tablets and evaluation of in vitro-in vivo correlation about this drug[J].The Journal of Pharmaceutical Practice,2008,26(3):211-213. |
| |
| Authors: | LE Jian LIU Qian SHI Jin-min and CHEN Gui-liang |
| |
| Institution: | Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Shanghai Institute for Food and Drug Control,Shanghai 201203,China;Shanghai Institute for Food and Drug Control,Shanghai 201203,China |
| |
| Abstract: | Objective: To study the dissolution of naproxen sodium tablets and evaluate in vitro / in vivo correlation.Methods: Dissolution test method in naproxen sodium tablets adopted by USP was used for determination of dissolution in vitro.The concentrations of naproxen sodium tablets in human plasma were determined by HPLC.Results:The linear equation based on the dissolution rate(X) and absorption percentage(F) was F=0.330 3X+0.699 8 and the correlation coefficient was 0.991 5.Conclusion:To a certain extent,the in vitro dissolution test in USP could reflect the in vivo absorption. |
| |
| Keywords: | naproxen sodium tablets dissolution in vitro and in vivo correlation |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《药学实践杂志》浏览原始摘要信息 |
| 点击此处可从《药学实践杂志》下载免费的PDF全文 |
|
