Effects of ventro-medial mesencephalic tegmentum (VMT) stimulation on the spontaneous activity of nucleus accumbens neurones: Influence of the dopamine system |
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| Authors: | C. Le Douarin J. Penit J. Glowinski A.M. Thierry |
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| Affiliation: | 1. Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;2. Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China;3. Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, China;4. Neuroscience Program, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;5. Microscopy CORE, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;6. Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;1. Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran;2. Institute for Brain Sciences and Cognition, Tarbiat Modares University, Tehran, Iran;1. Division of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy;2. National Institute of Neuroscience (INN), Italy;3. University of Utah, USA;4. Division of Neuropsychopharmacology, Department of Biomedical Sciences, University of Cagliari, 09042, Monserrato, Italy;1. University of South Carolina, 915 Green Street, Suite 506, Columbia, SC 29208, United States;2. University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, United States;3. University of South Carolina, Department of Psychology, 1512 Pendleton Street, Columbia, SC 29208, United States;4. Institute for Healthcare Improvement, 20 University Road, Cambridge, MA 02138, United States;1. Institute of Animal Breeding and Genetics, Department for Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria;2. Clinic for Reproduction and Large Animals, University of Ljubljana, Veterinary Faculty, Ljubljana, Slovenia;3. Institute for Preclinical Sciences, University of Ljubljana, Veterinary Faculty, Ljubljana, Slovenia;4. Agroscope, Swiss National Stud Farm, Avenches, Switzerland |
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| Abstract: | The effects of VMT-stimulation (100-500 microA, 0.6 ms; 1 Hz) on the spontaneous activity of neurones in the nucleus accumbens were analyzed in ketamine-anaesthetized rats. On spontaneously active cells (firing greater than 0.5 spikes/s), 3 types of responses were observed: either inhibition (36%), excitation (5%) or a composite sequence of excitation followed by inhibition (12%). Moreover, 14% of silent nucleus accumbens neurones were excited by single pulse VMT-stimulation. Finally, 3% of nucleus accumbens neurones recorded were driven antidromically by VMT-stimulation. Destruction of dopamine (DA) projections by 6-hydroxydopamine prevented the inhibitory responses to VMT stimulation in the great majority of cells studied, without affecting the excitatory responses. After systemic administration of haloperidol or sulpiride, the inhibitory responses to VMT stimulation were attenuated markedly, whilst the excitatory responses were, however, maintained. These results suggest that the inhibitory, but not the excitatory, effects of VMT-stimulation on nucleus accumbens neurones may be mediated by an activation of the mesolimbic DA system. |
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| Keywords: | nucleus accumbens ventro-medial mesencephalic tegmentum excitation inhibition dopamine haloperidol sulpiride |
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