Evidence that Stimulation of Megakaryocytopoiesis by Low Dose Vincristine Results from an Effect on Platelets |
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Authors: | Carl W Jackson Carol C Edwards |
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Institution: | Laboratory of Hematology, St Jude Children's Research Hospital, Memphis, Tennessee, U.S.A;. |
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Abstract: | S ummary . Appropriate low dosages of vincristine stimulate megakaryocytopoiesis and produce thrombocytosis. In this study of the thrombocytotic action of vincristine, administration of a single dose of 0.1 mg/kg to rats produced an increase in megakaryocyte concentration, diameter and 24 h 3H]thymidine labelling index. Transfusion of one body equivalent of platelets from normal donors prevented stimulation of megakaryocytopoiesis by vincristine whereas platelets from vincristine-treated donors did not. These results suggest that vincristine stimulates megakaryocytopoiesis by altering the functional role of circulating platelets in the regulation of thrombopoiesis. |
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