Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on- and off-conditions with FDG-PET |
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| Authors: | R Hilker J Voges A Thiel M Ghaemi K Herholz V Sturm W-D Heiss |
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| Institution: | (1) Department of Neurology, and, DE;(2) Department of Stereotaxy and Functional Neurosurgery, Medical University of Cologne, and, DE;(3) Max-Planck-Institut for Neurological Research Cologne, Cologne, Federal Republic of Germany, DE |
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| Abstract: | Summary. In order to compare the effects of high-frequency stimulation of the subthalamic nucleus (STN-DBS) and a levodopa-challenge
on cerebral metabolic activity, we conducted PET scans with 18F]2-fluoro-2-deoxyglucose (FDG) in the drug- and stimulation- on- and off-condition in a single patient suffering from advanced
PD. Our data revealed evidence for improved thalamocortical processing released from inhibition by overactive basal ganglia
output nuclei in both on-conditions. While levodopa also led to a reduction of lentiform hyperactivity, effective STN stimulation
seemed to interfere with distinct cerebellar and limbic circuits.
Received November 2, 2001; accepted January 15, 2002 Published online June 28, 2002 |
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| Keywords: | : Parkinson's disease deep brain stimulation positron emission tomography (PET) |
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