男性不育症患者的细胞遗传学分析

目的分析男性不育症患者细胞遗传学结果，探讨染色体异常对男性不育的影响。方法采用G显带方法，对468例男性不育症患者进行外周血染色体检查。结果468例不育症患者，101例染色体异常，染色体异常率为21．58％。染色体异常病例中，79．20％为Y染色体数目异常（80／101），6．93％为Y染色体结构异常（7／101）；0．89％（11／101）为常染色体结构异常，2．97％（3／101）为性反转。结论染色体异常，尤其是Y染色体异常对男性生育能力有重要的影响。

Cytogenetic analysis of patients with male infertility

Objective ： To analyse the cytogenetic examination results to investigate the effect of chromosome abnormalities on male infertility. Methods： The routine cytogenetic analysis was performed, including the chromosome G band analysis and karyotype analysis of the cultured peripheral blood lymphocytes. Results： 101 cases of chromosome abnormality were observed in 468 patients with male-infertility. The incidence of chromosome abnormality was 21.58%. Among the chromosome abnormalities： the incidence of Y chromosome numeric aberrations was 79. 20% ; the incidence of Y chromosome structural aberrations was 6. 93% ： the incidence of autosome structural aberrations was 10. 89% ; the incidence of sex reverse was 2. 97%. Conclusion： Chromosome abnormality, especially Y chromosome abnormality is an important factor resulting in patients with male infertility.