82例重症肺结核合并下呼吸道感染致病菌种的临床分析

目的　探讨重症肺结核患者下呼吸道致病菌种分布特点,细菌耐药情况。方法 选82例经纤支镜双套管保护性毛刷(PSB)培养发现致病菌株的重症肺结核患者,确定菌种后进行抗菌药物体外药敏检测。结果 82例患者PSB培养发现致病菌株98例次。其中革兰阴性杆菌55株(56.1%),革兰阳性球菌20株(20.4%),真菌23株(23.5%)。结论 重症肺结核患者呼吸道致病菌种以革兰阴性杆菌居多,但真菌感染亦明显增多,可能与患者免疫功能低下,长期滥用抗生素及不合理应用抗结核药物有关。

Clinical analysis of pathogenic bacteria from 82 cases with severe pulmonary tuberculosis complicated with lower respiratory tract infection

Objective To investigate the characteristics of the distribution and drugresistance of pathogenic bacteria in lower respiratory tract of severe pulmonary tuberculosis cases. Method The positive culture from protected specimen brush viabranchofibroscope from 82 cases with severe pulmonary tuberculosis were perfomed for gemspecies identification and drug sensitivity test in vitro. Results Total 98 pathogenicbacteria strains were found in PSB bacterial culture of 82 patients.There were 55 strainsof Gram-negative bacilli(56.1%);20 strains(20.4%) were Gram-positive Cocci;23 strains(23.5%) were fungi. Conclusion The primary pathogenic bacteria were Gram-negative bacilliin lower respiratory tract of the patients with severe pulmonary tuberculosis,and the fungi infection was distinctly rising.It might be related to immunod eficiency,antibiotic abuseand reasonless antituberculosis treatment.