| 肺纤维化中上皮-间质转型信号转导机制研究进展 |
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| 引用本文： | 粱冠男,胡永斌,周建华. 肺纤维化中上皮-间质转型信号转导机制研究进展[J]. 国际病理科学与临床杂志, 2008, 28(6): 9-503 |
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| 作者姓名： | 粱冠男 胡永斌 周建华 |
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| 作者单位： | 中南大学湘雅医学院病理系,长沙,410013 |
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| 基金项目： | 国家自然科学基金 ， 湖南自然科学基金(06JJ2098) This work was supported by the National Natural Science Foundation of China ， the Natural Science Foundation of Hunan.P.R. China |
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| 摘 要： | 肺泡上皮细胞向间质细胞转型是纤维化局灶成纤维细胞的重要来源，各种刺激因子作用于细胞受体，诱导细胞通路改变，从而对上皮-间质转型进行调控。对肺纤维化中上皮-间质转型信号转导调控机制的研究，为发展新的治疗策略提供了重要信息。
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| 关 键 词： | 肺纤维化 上皮-间质转型 信号转导 |
| 收稿时间： | 2008-05-12 |
| 修稿时间： | 2008-07-22 |
Progression of the signal transduction mechanisms of epithelial-mesenchymal transition in pulmonary fibrosis |
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| LIANG Guan-nan,HU Yong-bin,ZHOU Jian-hua. Progression of the signal transduction mechanisms of epithelial-mesenchymal transition in pulmonary fibrosis[J]. Journal of International Pathology and Clinical Medicine, 2008, 28(6): 9-503 |
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| Authors: | LIANG Guan-nan HU Yong-bin ZHOU Jian-hua |
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| Affiliation: | Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410013, China |
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| Abstract: | Alveolar epithelial cells(AECs) serve as an important source of myofibroblasts through epithelial-mesenchymal transition(EMT) in pulmonary fibrosis.Several stimulating factors act on cell receptors and regulate the process of EMT.The studies on the signal transduction mechanisms of EMT in pulmonary fibrosis can supply important information for therapeutic strategy. |
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| Keywords: | pulmonary fibrosis epithelial-mesenchymal transition(EMT) signal transduction |
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