A community study of clinical traits and risk factors for human metapneumovirus and respiratory syncytial virus infection during the first year of life |
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Authors: | Marie-Louise von Linstow Mette Høgh Svein Arne Nordbø Jesper Eugen-Olsen Anders Koch Birthe Høgh |
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Institution: | 1. Department of Paediatrics 531, Hvidovre University Hospital, Ketteg?rd Allé 30, DK - 2650, Hvidovre, Copenhagen, Denmark 2. Department of Clinical Microbiology, Hvidovre University Hospital, Copenhagen, Denmark 4. Department of Medical Microbiology, Trondheim University Hospital, Trondheim, Norway 3. Clinical Research Centre, Hvidovre University Hospital, Copenhagen, Denmark 5. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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Abstract: | Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are important respiratory pathogens with similar symptomatology.
The aim of this prospective birth cohort study was to identify risk factors for an hMPV or RSV infection during the first
year of life in unselected healthy children. We followed 217 children from birth to 1 year of age. Nasal swabs and symptom
diaries were collected monthly. Anti-hMPV and anti-RSV IgG antibodies by age 1 year were detected by ELISA, and nasal swabs
were analysed for hMPV and RSV by RT-PCR. Logistic regression was used for risk factor analysis. Anti-hMPV IgG was found in
38 children (17.5%), and anti-RSV IgG in 172 children (79%). Risk factors for being anti-hMPV IgG-positive were: (1) being
born in the spring (OR = 2.36; 95% CI:1.06–5.27), and (2) having older siblings (OR = 3.82; 95% CI:1.75–8.34). Risk factors
for being anti-RSV IgG-positive were: (1) gestational age <38 weeks (OR = 3.39; 95% CI:1.42–8.05), (2) increasing paternal
age (OR = 1.85 per 5 yrs; 95% CI:1.28–2.68), and (3) wall-to-wall carpeting (OR = 3.15; 95% CI:1.29–7.68). Being born in the
spring was associated with decreased odds of being anti-RSV IgG-positive (OR = 0.27, 95% CI:0.09–0.85). Risk factors for RSV
hospitalisation (n = 11) were: (1) older siblings (OR = 4.49; 95% CI: 1.08–18.73) and (2) smoking in the household (OR = 5.06; 95% CI: 1.36–18.76).
Exclusive breastfeeding for the first 14 days of life protected against hospitalisation (OR = 0.21; 95% CI:0.06–0.79). In
conclusion, this study identifies risk factors for mild and asymptomatic hMPV infections in infancy. |
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Keywords: | Metapneumovirus RSV Infants Children Risk factor |
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