| 健康人口服盐酸黄连素片剂后的尿药分析与药物代谢初步研究 |
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| 引用本文： | 余琛,张慧,潘俊芳,洪有采,任建英,朱大元,徐修容. 健康人口服盐酸黄连素片剂后的尿药分析与药物代谢初步研究[J]. 中国临床药理学杂志, 2000, 16(1): 36-39 |
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| 作者姓名： | 余琛 张慧 潘俊芳 洪有采 任建英 朱大元 徐修容 |
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| 作者单位： | 1. 上海市徐汇区中心医院,上海,200031
2. 中国科学院上海药物研究所,上海,200031 |
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| 摘 要： | 本文以13-甲基小檗碱为内标,用正相高效液相色谱-荧光检测的方法定量分析尿液中的小檗碱.考察了健康人一次口服 0.2g 盐酸黄连素糖衣片后 96h内小檗碱尿药排泄量变化,按矩量法求得其体内药物平均滞留时间(MRT)为32.63±6.15 h,累积尿药排泄量为 27.49±4.74μg;首次检测到小檗碱在人体内有四个未知的代谢峰.
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| 关 键 词： | 盐酸黄连素片 小檗碱 高效液相色谱法 药物代谢 血药浓度 |
Determination and Preliminary Studies of Metabolism of Berberine in Human Urine After Oral Administration |
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| YU Chen,ZHANG Hui,PAN Jun-Fang,HONG You-Cai,REN Jian-Ying,ZHU Da-Yuan,XU Xiu-Rong. Determination and Preliminary Studies of Metabolism of Berberine in Human Urine After Oral Administration[J]. The Chinese Journal of Clinical Pharmacology, 2000, 16(1): 36-39 |
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| Authors: | YU Chen ZHANG Hui PAN Jun-Fang HONG You-Cai REN Jian-Ying ZHU Da-Yuan XU Xiu-Rong |
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| Abstract: | A normal phase liquid chromatographicmethod (flurorescent detector) for determinating berberine (BER) concentration in humanurine was reported. The 13-methylberberine was used as the internal standard. A mixture ofdichloromethane-methanol-diethyl amine-acetic acid ( 90 90.40.5) was served as themobile phase. The dynamic change of excretion of BER in urine after oral administration of0.2 g BER.HCL tablets in single dosage was observed and MRT and AUC was calculed to be32.63±6.15 h and 27.49±4.74μg by statistical moment theory. Furthermore there were four metabolites ofberberine chloride in human urine were detected for the first time. |
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