| 肾结石大鼠Osteopotin mRNA的表达及猪苓汤和泽泻对其表达的影响 |
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| 引用本文： | 赖真,耿小茵,王耀帮,石之,张阮章,王沙燕. 肾结石大鼠Osteopotin mRNA的表达及猪苓汤和泽泻对其表达的影响[J]. 中国医师杂志, 2005, 7(4): 452-454 |
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| 作者姓名： | 赖真 耿小茵 王耀帮 石之 张阮章 王沙燕 |
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| 作者单位： | 暨南大学医学院附二院,深圳市人民医院中医科,广东,深圳,518020 |
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| 基金项目： | 广东省中医药管理局立项课题资助项目(99616) |
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| 摘 要： | 目的探讨猪苓汤及泽泻对肾结石大鼠骨桥蛋白(OPN)mRNA表达的影响。方法采用乙醛酸溶液制作大鼠肾结石模型,用反转录聚合酶链反应(RT-PCR)技术检测肾结石大鼠OsteopotinmRNA的表达。结果诱石剂可使大鼠肾脏OPNmRNA的表达量明显增加(P<0.05);而猪苓汤及泽泻则可抑制OPNmRNA的表达(P<0.05)。结论初步揭示猪苓汤及泽泻对肾结石大鼠OsteopotinmRNA表达的变化规律,从而为临床疾病的防治及治疗提供一定的依据。
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| 关 键 词： | 肾结石 猪苓汤 大鼠 泽泻 表达及 反转录聚合酶链反应 mRNA表达 骨桥蛋白 技术检测 PCR） 变化规律 临床疾病 OPN 乙醛酸 表达量 |
| 修稿时间： | 2004-09-13 |
The Effects of Zhu Ling Decoction and Alisma Orientalis on Osteopotin RNA Expression in the Experimental Rat Model of Renal Stone |
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| LAI Zhen,GENG Xiao-ying,WNAG Yao-bang,et al.. The Effects of Zhu Ling Decoction and Alisma Orientalis on Osteopotin RNA Expression in the Experimental Rat Model of Renal Stone[J]. Journal of Chinese Physician, 2005, 7(4): 452-454 |
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| Authors: | LAI Zhen GENG Xiao-ying WNAG Yao-bang et al. |
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| Affiliation: | LAI Zhen,GENG Xiao-ying,WNAG Yao-bang,et al. Shenzhen People's Hospital,The Second Affiliated Hospital,Jinan University Medical College,Shenzhen 51802,China |
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| Abstract: | Objective To explore the effects of Zhu Ling decoction and Alisma orientalis on the osteopotin mRNA expression in the experimental rat model of renal stone. Methods The experimental rat model of renal stone was set up using glyoxylic acid. Osteopontin mRNA expression in the renal tissues in the experimental rat model of renal stone was detected by RT-PCR. Results Glyoxylic acid obviously increased osteopontin mRNA expression in the renal tissues. Zhu Ling decoction and Alisma orientalis remarkably decreased the expression of osteopontin mRNA in the renal tissues. Conclusion Zhu Ling decoction and Alisma orientalis could decrease the osteopotin mRNA expression in the renal tissues in the experimental rat model of renal stone. The results were helpful for prevention and treatment of renal stone. |
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