恶性淋巴瘤细胞形态学的研究 曲核细胞和裂核细胞的识别

应用光镜对非何杰金氏淋巴瘤的扭曲核细胞和裂核细胞的核形态特点和相互区别作了详细观察。曲核细胞和裂核细胞的核形态和染色质分布等均有不同特征,光镜下可识别和区分,进而可根据瘤细胞的形态来确定肿瘤的T或B细胞起源。此外,扭曲核细胞和裂核细胞形态有交叉现象,呈曲裂难分,形态学诊断时应予注意。

A morphological Study of Malignant Lymphoma Cells ——The discrirmination of the Convoluted and the Cleaved Cells

The convoluted and the cleaved cells are two distinct cell types of nonHodgkin's lymphoma, the former is derived from T-cell and the latter from B-cell, This study was made to discriminate the morphological features of the nucleus between the two cell types with oil-immersion objective by light microscopy. The results showed that each type has distinct charcteristics of nuclear shape and chromatin distribution, by which the two cell types may be easily differentiated. Upon discerning the two cell types, we may recognize the tumors of T-cell or B-cell origin. However, the diagnosis should not be based upon a few specific cells, but must be dependent on the nuclear configuration of most cells and general histological features. In fact, overlap of nuclear shape of the two cell types may be observed. As the morphological method was chiefly used in this study, it is possible that this method is more realistic for the routine clinical pathological diagnosis of malignant lymphomas.