吉兰-巴雷综合征患者脑脊液中S-100b、MBP的检测及意义

目的 研究吉兰-巴雷综合征(green-barre syndrome,GBS)患者脑脊液中S-100 b和髓鞘碱性蛋白(MBP)的含量变化,探讨S-100 b及MBP在GBS发病过程中的作用以及与病情严重程度的关系.方法 采用酶联免疫吸附法(ELISA)测定32例不同临床分级的GBS患者(GBS组),30例其他神经系统...

Analysis of the significance on the levels of S-100b and MBP in CSF of patients with Guillain-Barre syndrome

Objective To study the contents of S-100b and myelin basic protein(MBP) in CSF of patients with Guillain-Barre syndrome,and explore the role in the pathogenesis of GBS and their relation to disease severity.Methods The contents of S-100b and MBP in CSF were measured by a sandwich enzyme-linked immunosorbent assay(ELISA) in 32 patients with different clinical classification of GBS(GBS group),and 30 patients with other neurological diseases(OND group) and 29 normal healthy controls(NC group).Results The contents of S-100b and MBP increased in CSF of GBS group,and were proportional to the degree of condition(P<0.05),were higher than that in OND group and NC group(P<0.05),but there was no statistically significant difference between OND group and NC group(P>0.05).Conclusion The contents of S-100b and MBP in CSF of patients with GBS increased significantly,with more serious,S-100b and MBP content increased higher.S-100b promoted the inflammation development in the course of GBS,MBP responded to myelin damage,they played an important role in the pathogenesis of GBS.