| 柴苓调肝颗粒剂治疗大鼠非酒精性脂肪性肝病的实验研究 |
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| 引用本文： | 潘洋,王炎杰,张晓忠,房莹莹.柴苓调肝颗粒剂治疗大鼠非酒精性脂肪性肝病的实验研究[J].中国中西医结合消化杂志,2010,18(2). |
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| 作者姓名： | 潘洋 王炎杰 张晓忠 房莹莹 |
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| 作者单位： | 黑龙江省中医研究院,消化科,黑龙江,哈尔滨,150036 |
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| 基金项目： | 黑龙江省科学技术厅攻关项目(GC07C340) |
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| 摘 要： | 目的]探讨柴苓调肝颗粒剂治疗大鼠非酒精性脂肪性肝病(NAFLD)的作用机制。方法]采用高脂饲料的方法制备大鼠NAFLD模型,造模成功后,随机分为7组,柴苓调肝颗粒剂高、中、低剂量(高、中、低剂量)组,甘乐对照(甘乐)组、三七脂肝丸对照(三七脂肝丸)组、模型对照(模型)组和饮食控制组,另设正常对照(正常)组未予造模。各组分别给予相应的处理,4周后检测各组血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)、肿瘤坏死因子α(TNF-α)和瘦素(LP)以及肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、体重及肝重指数的变化。结果]高剂量组各项指标与模型组和饮食控制组比较差异均有统计学意义(P0.05,0.01),与正常组比较(P0.05)。结论]柴苓调肝颗粒剂可有效治疗实验性NAFLD。
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| 关 键 词： | 肝病 非酒精性脂肪性 柴苓调肝颗粒剂 实验研究 |
Experimental research on treatment of non-alcoholic fatty liver disease in rats with Chailingtiaogan Granule |
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| PAN Yang,WANG Yan-jie,ZHANG Xiao-zhong,FANG Ying-ying.Experimental research on treatment of non-alcoholic fatty liver disease in rats with Chailingtiaogan Granule[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2010,18(2). |
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| Authors: | PAN Yang WANG Yan-jie ZHANG Xiao-zhong FANG Ying-ying |
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| Institution: | PAN Yang,WANG Yan-jie,ZHANG Xiao-zhong,FANG Ying-ying(Department of Gastroenterology,Heilongjiang TCM Institution,Ha\'erbin 150036,China) |
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| Abstract: | Objective]To investigate the mechanism and action of Chailingtiaogan Granule in treating experimental non-alcoholic fatty liver disease(NAFLD)in rats.Methods]The NAFLD rat model was made by feeding with high lipid diet.All of the rats were randomly divided into 8 groups which included Chailingtiaogan Granule high-dose group,middle-dose group,low-dose group,Ganle group,Sanqizhigan Wan group,model group,diet control group and normal control group,when it was successfully confirmed that the rats were sufferi... |
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| Keywords: | non-alcoholic fatty liver disease Chailingtiaogan Granule experimental research |
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