Isolation and characterization of a unique C57BL B-tropic virus |
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| Authors: | L E Benade R H Bassin J N Ihle J C Lee A Rein |
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| Institution: | 1. Cancer Biology Program, NCI Frederick Cancer Research Center, Frederick, Maryland 21701, USA;2. Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland 20014, USA |
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| Abstract: | A unique B-tropic virus (CS43) has been isolated from a C57BL mouse. This virus differs from those we have previously characterized and from several isolates we have obtained from normal and leukemic C57BL mice. Unlike other C57BL B-tropic viruses, CS43 does not have a p12 polypeptide homologous to that of the class II xenotropic virus, but does have a p12 homologous to that of AKR MuLV (class I). In common with the other C57BL B-tropic isolates, CS43 has an altered major core protein (p30), which competes only weakly in a class-specific assay that distinguishes ecotropic MuLV p30s from those of xenotropic origin. The data are compatible with a unique recombinational event in the generation of this isolate, which should prove useful in studying the origin of B-tropic viruses and the properties that determine N/B tropism. |
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| Keywords: | To whom reprint requests should be addressed |
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