| 月桂氮芯卓酮促阿司匹林透皮吸收作用 |
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| 引用本文： | 边佳明,赵维娟,许景峰.月桂氮芯卓酮促阿司匹林透皮吸收作用[J].中国医院药学杂志,2002,22(1):24-26. |
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| 作者姓名： | 边佳明 赵维娟 许景峰 |
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| 作者单位： | 北京军区总医院,北京,100700 |
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| 摘 要： | 目的：研究不同浓度的月桂氮Zhuo酮对阿司欧林小鼠离体皮肤渗透性的影响。方法：用改良的Franze扩散池，选不同浓度的月桂氮Zhuo酮（0％，2％，5％）作促渗剂，紫外法测定药物累积释放量（Q）、稳态流量（J）、渗透系数（KP）。结果：含2％和5％月桂氮Zhuo酮的乳膏的稳态流量（J）分别比空白乳膏增加14．9％和6．6％。结论：含不同浓度的月桂氮Zhuo酮均可促进阿司匹林的透过，药物从乳剂型基质向皮肤的渗透符合Higuchi方程。
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| 关 键 词： | 月桂氮Zhuo酮 阿司匹林 透皮吸收 |
| 文章编号： | 1001-5213(2002)01-0024-03 |
| 修稿时间： | 2001年2月20日 |
action of azone for perceutanous absorption of aspirin |
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| BIAN Jia-Ming,ZHAO Wei-Juan,XU Jing-Feng.action of azone for perceutanous absorption of aspirin[J].Chinese Journal of Hospital Pharmacy,2002,22(1):24-26. |
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| Authors: | BIAN Jia-Ming ZHAO Wei-Juan XU Jing-Feng |
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| Abstract: | OBJECTIVE To study the influence of different concentration of azone(0%,2%,5%) in aspirin ointment on drug permeation of rats skin in vitro.METHODS The improved Franze diffusing cell was applied. Accumulative permeation quantity (Q),steady percutaneous speed (J) and permeation coefficient (KP) were determined by UV.RESULTS Steady percutanous speed (J) of aspirin ointment with 2% and 5% azone increased 14.9% and 6.6% respectively.CONCLUSIONS Different concentration of azone can enhance permeation of asprin.The permeation from emulsion base to skin conformed to Higuchi equation. |
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| Keywords: | azone aspirin percutaneous absorption |
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