| 功能磁共振成像评价帕金森患者静息状态下脑功能连接 |
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| 引用本文： | 陈俊,刘波,刘岘,陈志光,李宁娜,雒晓东. 功能磁共振成像评价帕金森患者静息状态下脑功能连接[J]. 中国医学影像技术, 2009, 25(6): 989-992 |
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| 作者姓名： | 陈俊 刘波 刘岘 陈志光 李宁娜 雒晓东 |
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| 作者单位： | 1. 广东省中医院影像科,广东,广州,510120
2. 广东省中医院神经内科,广东,广州,510120 |
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| 摘 要： | 目的 采用功能磁共振成像(fMRI)评价帕金森病(PD)患者静息状态下脑功能连接的特点. 方法 对14例符合PD诊断标准的患者及14名健康者行静息态脑fMRI,选双侧壳核为感兴趣区,PD患者与正常对照组间脑功能连接的差异用随机效应两样本t检验.结果 与正常对照组相比,PD患者在静息状态下前额叶中内侧、双侧尾状核头部、左侧脑岛、左侧梭状回等脑区功能连接减低;双侧小脑半球、双侧舌回、双侧颞中回、右中央前回、右侧额上回、右侧额下回、右侧扣带回后部、左侧额中回等脑区功能连接增强.结论 PD患者在静息状态下存在异常的脑功能连接网络.
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| 关 键 词： | 帕金森病 静息状态 功能磁共振成像 |
| 收稿时间： | 2008-08-18 |
| 修稿时间： | 2009-02-24 |
Functional MRI investigation of brain functional connectivity in resting-state of Parkinson's disease patients |
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| CHEN Jun,LIU Bo,LIU Xian,CHEN Zhi-guang,LI Ning-na and LUO Xiao-dong. Functional MRI investigation of brain functional connectivity in resting-state of Parkinson's disease patients[J]. Chinese Journal of Medical Imaging Technology, 2009, 25(6): 989-992 |
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| Authors: | CHEN Jun LIU Bo LIU Xian CHEN Zhi-guang LI Ning-na LUO Xiao-dong |
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| Affiliation: | Department of Radiology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China;Department of Radiology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China;Department of Radiology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China;Department of Radiology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China;Department of Radiology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China;Department of Neurology, Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou 510120, China |
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| Abstract: | |
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| Keywords: | Parkinson disease Resting-state Functional magnetic resonance imaging |
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