培多普利逆转肾血管性高血压大鼠心肌肥厚及对心功能的影响

目的探讨血管紧张素转换酶抑制剂—培多普利在逆转两肾一夹高血压大鼠心肌肥厚过程中对心功能的影响。方法两肾一夹法制作肾性高血压大鼠模型,通过心脏超声和心室内插管,以射血分数(EF)和左室短轴缩短率(FS)、零负荷下等容收缩期心肌纤维收缩成分的最大缩短速度(Vmax)作为心脏收缩功能指标,以左心室舒张末压(LVEDP),等容舒张期压力下降的时间常数(T)作为心脏舒张功能指标。结果培多普利在逆转心肌肥厚同时,可使心肌肥厚时升高的LVEDP、T值下降,同时对心脏EF、FS和Vmax值无明显影响。结论培多普利在逆转两肾一夹高血压大鼠心肌肥厚同时,可改善大鼠心脏舒张功能。

The Effect of Perindopril on Cardiac Hypertrophy and Function in Renovascular Hypertensive Rats

Objective To determine the effect of angiotensin converting enzyme inhibitor-perindopril on the cardiac function while it reverses the cardiac hypertrophy in renovascular hypertensive rats.Methods The renovas-cular hypertension was induced by two kidney-one clip methods.Cardiac function was determined by echocardiography and hemodynamical analysis,ejection fraction(EF) and fractional shortening(FS) and Vmax was measured as the index of cardiac systolic function,while left ventricular end diastolic pressure(LVEDP) and time constant(T) was measured as the index of cardiac diastolic function.Results Perindopril could down regulate the LVEDP and T values during it induced the regression of cardiac hypertrophy,while there was no change about EF,FS and Vmax.Conclusion Perindopril could improve cardiac diastolic function when it induced the regression of cardiac hypenrophy in renovascular hypertensive rats.