雷帕霉素洗脱支架临床应用1年随访

目的:评价雷帕霉素洗脱支架(CypherTM)1 a的安全性及有效性. 方法:回顾分析112例接受CypherTM支架置入术冠心病患者的即刻疗效和临床随访结果. 结果:共处理112例患者173处病变,置入支架227枚,其中132处病变置入159枚CypherTM支架. 除2处严重钙化病变需辅以高压球囊才能充分扩张,1处支架近端发生内膜撕裂,其余全部成功置入. 手术过程及住院期间无严重并发症发生,成功率98.1%. 112例患者中102例得到随诊,平均随访1 a(≥12 mo),1例死亡,10例患者心绞痛再发,其中,6例为普通金属支架内的再狭窄(6例中1例伴CypherTM支架内近端再狭窄),4例为其他分支的新病变. 30例复查了冠状动脉造影,1例CypherTM支架内近端再狭窄. 结论:CypherTM支架临床应用安全,能显著降低再狭窄率.

One year follow-up on the efficacy and safety of CypherTM stent applied to treat coronary heart disease

AIM: To investigate the efficacy and safety of rapamycin eluting stents(Cypher~(TM)) during 1-year follow-up.METHODS: The immediate angiographic and clinical follow-up outcomes were analyzed retrospectively in 112 patients who had received Cypher~(TM).RESULTS: One hundred and seventy-three lesions were treated and 227 stents were implanted in the 112 patients.One hundred and fifty-nine slow release rapamycin eluting stents were implanted in 132 lesions.The Cypher~(TM) stents were successfully implanted in 156/159 lesions(98.1%).High pressure balloon was used for stent deployment in 2 lesions with severe calcification.Dissection occurred at the distal side of stent in 1 lesion.No serious complications were found during operation and hospitalization.Clinical follow-up of 102 patients was conducted for 12 months and 1 patient died of cardiac death and angina pectoris occurred in 10 patients.Angiography was conducted again in the all 10 patients,and 6 restenosis in bare stents and 4 new lesions in other coronary arteries were found.Angiography was performed for a second time in 30 of 112 followed-up patients,showing only 1 restenosis in Cypher~(TM) stent.CONCLUSION: Cypher~(TM) is safe and effective in the treatment of coronary lesions.