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| 栀子苷溶液鼻黏膜吸收规律的研究 | |
| 引用本文： | 万娜 张海燕 许润春 郑琴 杨明. 栀子苷溶液鼻黏膜吸收规律的研究[J]. 中国中药杂志, 2009, 34(7): 839 |
| 作者姓名： | 万娜 张海燕 许润春 郑琴 杨明 |
| 作者单位： | 1. 江西中医学院,现代中药制剂教育部重点实验室,江西,南昌,330004 2. 成都中医药大学,四川,成都,610075 3. 江西中医学院,现代中药制剂教育部重点实验室,江西,南昌,330004;成都中医药大学,四川,成都,610075 |
| 基金项目： | 江西省教育厅科学技术研究项目(GJJ08335)；江西省卫生厅中医科研计划赣卫中字［2007］20号 |
| 摘 要： | 目的:研究栀子苷溶液的鼻黏膜吸收规律.方法:以大鼠在体鼻循环法为实验模型,考察在不同循环液的体积、流速、药物浓度等条件下栀子苷溶液的鼻黏膜吸收规律.结果:栀子苷在鼻黏膜洗出液中稳定性良好,当循环液体积为5 mL,流速2.5 mL·min~(-1)时栀子苷溶液鼻黏膜吸收速率常数不随药物浓度发生变化.结论:栀子苷溶液鼻黏膜吸收机制为被动扩散,吸收符合一级动力学特点,吸收速率常数K为4.20×10~(-3). |
| 关 键 词： | 栀子苷 鼻黏膜 吸收 鼠在体循环法 |
Evaluation of nasal absorption for geniposide solution |
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| MO Na-,Zhang-Hai-Yan-,Hu-Run-Chun-,Zheng-Qin-,Yang-Meng-. Evaluation of nasal absorption for geniposide solution[J]. China Journal of Chinese Materia Medica, 2009, 34(7): 839 | |
| Authors: | MO Na- Zhang-Hai-Yan- Hu-Run-Chun- Zheng-Qin- Yang-Meng- |
| Affiliation: | 1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Nanchang 330004, China; 2. Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China |
| Abstract: | Objective: To investigate the regulation of geniposide nasal absorption. Method: We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied. Result: Geniposide was stable in rats' nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL·min-1, the absorption rate of geniposide remains constant in a dose independent manner. Conclusion: The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20×10-3. |
| Keywords: | geniposide nasal mucosa absorption in situ rat nasal recirculation method |
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