恶性肿瘤化疗应用格拉司琼止吐的临床研究

目的探讨格拉司琼用于恶性肿瘤患者化疗止吐的最佳用药时间。方法按入院先后顺序将99例肺癌患者分为甲、乙、丙3组,分别于化疗前10、30、60分钟静脉推注格拉司琼3 mg,观察用药后恶心呕吐情况,连续观察7天,比较3组患者恶心、呕吐发生率,恶心、呕吐反应程度和患者不良反应。结果 3组患者化疗后的呕吐发生率分别为75.8%、54.5%、81.8%;乙组无恶心、呕吐者较两组多,而难控制的呕吐者较另两组少（P=0.003）;不良反应有头晕、头痛、腹部不适和便秘,3组不良反应比较差异无统计学意义（P=0.975）。结论在恶性肿瘤化疗前30分钟应用格拉司琼止吐的效果最好。

Application of antiemetic Granisetron during cancer chemotherapy

Objective To study the best medication time to inject Granisetron as antiemetic during cancer chemotherapy.Methods Ninety-nine cases of lung cancer patients were randomized into three groups,group A,group B and group C.Group A,B and C were intravenously injected 3 mg of Granisetron 10,30 and 60 minutes before chemotherapy respectively.The symptom of nausea and vomiting was observed after intravenous injection for 7 days.Results The antiemetic effect of group B was significantly superior to that of group A a...