Tubular marker excretion in children from families with Balkan nephropathy |
| |
Authors: | Vladisav Stefanovic Rade Cukuranovic Vidosava Djordjevic Ivan Jovanovic Nevenka Lecic Milena Rajic |
| |
Institution: | (1) Institute of Nephrology, Faculty of Medicine, Bul. Zorana Djindjica 81, 18000 Nis, Serbia |
| |
Abstract: | Balkan nephropathy (BN) has not been described in children; however, some previous studies in children from families with
BN have revealed abnormalities of the urinary tract. In this study, urinary excretion of β2-microglobulin, N-acetyl-β-D-glucosaminidase
(NAG) and gamma-glutamyl transpeptidase (GGT) was studied three times a year: spring, autumn, and winter, during a 3-year
period, in 703 healthy children, initial age 9–13, from endemic and nonendemic settlements around the South Morava River.
Beta-2-microglobulin excretion in urine, in all three seasons, was highest in children from families with BN compared with
the excretion in children from the city, nonendemic villages, and those from nonendemic families. Increased urinary GGT excretion
in children from endemic villages in October was higher than in children from the city and control villages, being the same
in both endemic and nonendemic families. However, in February, it was similar in children from the city, endemic, and control
villages. In conclusion, children from families with BN excreted significantly more β2-microglobulin in all three seasons
(spring, autumn, winter) of the study, in multivariate analysis significant for family status, gender, and the season (p < 0.001). NAG emerged as a potentially useful marker for seasonal exposure to an environmental nephrotoxin. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|