氨溴索和戊乙奎醚用于治疗急性呼吸窘迫综合征的临床观察

目的 探讨盐酸氨溴索和盐酸戊乙奎醚治疗呼吸窘迫综合征的疗效及安全性.方法 创伤性湿肺所致急性呼吸窘迫综合征并行气管插管机械通气成年患者28例,随机分为氨溴索（沐舒坦）组（M组）、沐舒坦-盐酸戊奎醚（长托宁）组（M-C组）.入室后重症监护,其他镇静评分和治疗方法相同.M组沐舒坦300 mg静脉滴注,每天二次；M-C组沐舒坦300 mg,静脉滴注,每天二次,长托宁1 mg肌注,每天一次.观察患者72 h内排痰量和痰液性质,撤机拔管时间及ICU住院时间.结果 M-C组与M组比较每天排痰量明显减少；撤机拔管时间明显缩短（P ＜0.05）.结论 氨溴索与戊乙奎醚联合使用治疗急性呼吸窘迫综合征临床效果显著.

Clinical efficacy of ambroxol plus penehyclidine in the treatment of acute respiratory distress syndrome

Objective To observe the curative effect and safety of ambroxol （mucosolvan）plus penehyclidine in the treatment of acute respiratory distress syndrome（ARDS）.Methods A total of 28 adult patients with ARDS caused by traumatic wet lung were treated by tracheal intubation and mechanical ventilation after entering the intensive care unit.The patients were randomly divided into two groups.Patients in the mucosolvan group（M group）were treated by ambroxol（300 mg,iv drip,bid）,while other patients （MC group）were treated by the isodose ambroxol plus penehyclidine（1 mg,im,qd）.The volume and property of sputum during 72 hours treatment,ventilator extubation time,and length of ICU stay were observed.Results Patients in the MC group expectorated less sputum than that in the M group（P ＜ 0.05）.The time of ventilator weaning in the MC group also reduced（P ＜ O.05）.There was no severe untoward reaction occurred in the two groups.Conclusion The combination of ambroxol plus penehyclidine is an effective method in the treatment of ARDS.