Interleukin-1 beta release from human peripheral blood monocytes associated with phagocytosis of carbonyl-iron or erythrocytes |
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| Authors: | M Okamoto M Sasano M Goto K Nishioka S Aotsuka K Nakamura R Yokohari T Miyamoto |
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| Affiliation: | Institute of Rheumatology, Tokyo Women's Medical College, Japan. |
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| Abstract: | Interleukin-1 beta (IL-1 beta) release from human peripheral blood monocytes during the incubation with carbonyl-iron or sheep red blood cells was investigated. The incubation of purified monocytes with carbonyl-iron or sheep red blood cells enhanced IL-1 beta release, while their compounds, hemoglobin, globin and ferric citrate did not. The mechanisms of IL-1 beta release by carbonyl-iron or sheep red blood cells may be related to their phagocytosis, as non-phagocytic monocytes did not release IL-1 beta. |
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