| 鞘内注射孤啡肽对不同小鼠所致痛觉超敏的比较 |
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| 引用本文： | 孟美金,Ting Wee Lee,吴新民,Lee Tat Leang. 鞘内注射孤啡肽对不同小鼠所致痛觉超敏的比较[J]. 中华麻醉学杂志, 2003, 23(9): 671-674 |
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| 作者姓名： | 孟美金 Ting Wee Lee 吴新民 Lee Tat Leang |
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| 作者单位： | 1. 100034,北京大学第一医院麻醉科
2. 新加坡国立大学医院麻醉科 |
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| 摘 要： | 目的：比较鞘内注射孤啡肽在Swiss albino和C57BL两种小鼠中所引发的痛觉超敏的特点。方法：以随机、双盲、画笔轻触法，观察鞘内注射孤啡肽50min内两种小鼠痛觉超敏反应。结果：在Swiss albino小鼠中，孤啡肽引起的痛觉超敏持续50min，在5fmol--50pmol的剂量范围内，没有观察到量效关系。在C57BL小鼠中，孤啡肽引起的痛觉超敏持续30min，在10fmol～1nmol的剂量范围内，呈现出钟形的量效曲线。结论：鞘内注射孤啡肽的作用有小鼠种系间的区别。
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| 关 键 词： | 鞘内注射孤啡肽 小鼠 痛觉超敏 比较 脊髓 |
| 修稿时间： | 2002-12-10 |
Comparison of allodynic effect induced by intrathecal administration of nociceptin between two mouse strains |
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| Ting Wee Lee,Michel George Ricos,Lee Tat Leang,Tachibana Shinro. Comparison of allodynic effect induced by intrathecal administration of nociceptin between two mouse strains[J]. Chinese Journal of Anesthesilolgy, 2003, 23(9): 671-674 |
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| Authors: | Ting Wee Lee Michel George Ricos Lee Tat Leang Tachibana Shinro |
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| Abstract: | Objective To compare the allodynic effect of intrathecal nociceptin between Swiss albino and C57 BL mice. Methods The allodynic effect was evaluated by allodynic scores by light touching using paintbrush. The allodynic effect of intrathecal nociceptin was observed over 50 min after injection in two mouse strains in a double blind manner. Results The allodynia induced by nociceptin lasted for 50 min in Swiss albino and no dose-response relationship was observed from dose 5 fmol- 50 pmol per mouse. In C57 BL mice, allodynic effect lasted for 30 min and showed a bell-shaped dose-response curve from dose 10 frnol-1 nmol per mouse. Conclusion These results demonstrate that the allodynic eflect of intrathecal nociceptin is different between strains. |
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| Keywords: | Endorphins Hyperalgesia Injections spinal |
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