Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens |
| |
Authors: | Enrico Girardi Igor Maricic Jing Wang Thien-Thi Mac Pooja Iyer Vipin Kumar Dirk M Zajonc |
| |
Institution: | Division of Cell Biology, La Jolla Institute for Allergy & Immunology, La Jolla, California, USA. |
| |
Abstract: | Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR α-chains and TCR β-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|