| 恒磁场对大鼠脑缺血-再灌注模型抗氧化能力的影响 |
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| 引用本文： | 许艳,宋晓燕,马波,高佩琦.恒磁场对大鼠脑缺血-再灌注模型抗氧化能力的影响[J].中国血液流变学杂志,2004,14(1):22-24,39. |
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| 作者姓名： | 许艳 宋晓燕 马波 高佩琦 |
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| 作者单位： | 哈尔滨医科大学生物物理教研室,哈尔滨,150086 |
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| 摘 要： | 目的研究恒磁场对脑缺血再灌注大鼠抗氧化能力的影响.方法大脑中动脉线栓法建立脑缺血90min再灌注模型,40mT恒磁场体外照射大鼠头部30min/d,共7d,测MDA、SOD(T-SOD,CuZu-SOD,Mn-SOD)、GSH-PX、T-AO、CP的变化.结果磁疗组中的MDA显著低于模型组,T-SOD,CuZu-SOD,T-AO,CP显著高于模型组,Mn-SOD,GSH-PX相对模型组有增高趋势,但不显著.结论恒磁场能在一定程度上提高大鼠脑缺血-再灌注模型的抗氧化能力.
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| 关 键 词： | 恒磁场 脑缺血-再灌注 抗氧化能力 |
| 文章编号： | 1009-881X(2004)01-0022-03 |
Effect of Constant Magnetic Field on Antioxidation Ability of Rats during Cerebral Ischemia-reperfusion |
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| XU Yan,SONG Xiao-yan,MA Bo,GAO Pei-qi.Effect of Constant Magnetic Field on Antioxidation Ability of Rats during Cerebral Ischemia-reperfusion[J].Chinese Journal of Hemorheology,2004,14(1):22-24,39. |
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| Authors: | XU Yan SONG Xiao-yan MA Bo GAO Pei-qi |
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| Abstract: | Objective To study the effect of constant magnetic field on antioxidation ability of rats during ischemia-reperfusion injury.Method The rats were given cerebral ischemia for 90 min by using suture method,then reperfused for 7 days. During the 7 days,rats in magnetic therapy group were exposed to 40mT constant magnetic field, then to measure the changes of MDA,SOD(T-SOD,CuZu-SOD, Mn-SOD),GSH-PX,T-AO and CP.Results MDA content in magnetic therapy group is significantly lower than that in model group.T-SOD,CuZu-SOD,CP activity and T-AO content in magnetic therapy group is significantly higher than that in model group,Mn-SOD,GSH-PX activity in magnetic therapy group is higher than that in model group,but not significantly.Conclusion To some extent,the constant magnetic field can increase the antioxidation ability of rats during cerebral ischemia-reperfusion injury. |
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| Keywords: | constant magnetic field cerebral ischemia-reperfusion antioxidation ability |
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