七氟醚预处理对缺血/再灌注心肌的保护作用

为观察七氟醚预处理对左冠脉前降支阻断 3h后再灌注 3h的在体兔心的保护作用 ,48只新西兰白兔随机分成对照组、缺血预处理组、七氟醚预处理组、缺血预处理 +优降糖 (三磷酸腺苷敏感的钾离子通道阻断剂 )组、七氟醚 +优降糖组及单纯优降糖组。结果显示缺血预处理组和七氟醚预处理组心肌梗死面积与缺血面积的比率比对照组显著减少 (P <0 .0 5 ) ,凡加用优降糖的各组与对照组相比差异无显著性 (P <0 .0 5 )。各组血流动力学指标在各时间点差异无显著性。提示七氟醚预处理对缺血 3h后再灌注 3h的在体兔心具有保护作用 ,其机制与激活三磷酸腺苷敏感的钾离子通道有关。

Protective effects of sevoflurane pretreatment on myocardial ischemia reperfusion injury in rabbits

To observe the myocardial protective effects of sevoflurane pretreatment on ischemia reperfusion injury, forty eight rabbits were divided into six groups randomly: control group, ischemia preconditioning group, sevoflurane preconditioning group, ischemia preconditioning plus glyburide group, sevoflurane preconditioning plus glyburide group, glyburide group, each group subjected to three hours of left anterion descending coronary artery occlusion followed by three hours of reperfusion. Infarct size and area at risk were defined by staining. Infarct size [expressed as a percentage of the area at risk (IS:AR)] was (60.8±10.8)% in controls, and reduced to (33.1±4.9)% and (30.9±6.8)% respectively in ischemic preconditioning groups and sevoflurane preconditioning groups. Glyburide pretreatment eliminated the preconditioning effects of ischemia and sevoflurane [IS:AR=(59.3±11.2)% and (56.6±11.9)%, respectively; not significant]. Glyburide alone did not increase infarct size [IS:AR=(63.2±12.5)%, not significant]. It suggests that sevoflurane pretreatment protects the rabbit heart subjected to three hours of coronary occlusion from infarction.