一种血液相容性良好的亲水性聚氨酯材料

背景:当聚氨酯材料与活体组织相接触时,会导致一些不良反应,诸如血栓形成和炎症反应。目的:通过混合亲水性软段来改善聚氨酯材料的亲水性,从而制得抗凝血性能较好的聚氨酯材料。方法:以聚四氢呋喃、聚乙二醇作为混合软段,4,4’-二苯基甲烷二异氰酸酯为硬段,然后在扩链剂1,4-丁二醇以及催化剂二丁基二月桂酸锡的条件下以预聚法合成一系列聚氨酯材料。结果与结论:增加聚乙二醇的含量,聚氨酯材料的亲水性提高。软段中含有聚乙二醇的聚氨酯材料依然能够保持聚氨酯材料优良的机械性能,血小板黏附较少,抗凝血性较好。提示通过在聚氨酯合成原料的软段中添加聚乙二醇,可以提高聚氨酯材料的亲水性和血液相容性。

A hydrophilic polyurethane material with good blood compatibility

BACKGROUND: When polyurethane materials are in contact with living organisms, they can cause adverse biological reactions, for example, forming thrombus and inflammation. OBJECTIVE: To improve the hydrophilicity of polyurethane materials through a mixture of hydrophilic soft segments so as to obtain a polyurethane material with better anticoagulant properties. METHODS: Polyurethane films were synthesized with polytetrahydrofuran and polyethylene glycol as mixed soft segments, 4, 4’-diphenylmethane diisocyanate as the hard segment, and then in the chain extender 1, 4-butanediol and the catalyst dibutyltin dilaurate conditions to obtain a series of polyurethane materials. RESULTS AND CONCLUSION: The results showed that hydrophilic and blood compatibility properties of polyurethane films were enhanced, with the increase of the content of polyethylene glycol. Lu J, Zhou HJ, Shi HT, Qian YF, He CL, Liang CX, Li L. A hydrophilic polyurethane material with good blood compatibility. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(42): 7827-7830. http://www.crter.cn http://en.zglckf.com] Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing 210097, Jiangsu Province, China