| 脑缺血再灌注损伤模型大鼠参附注射液干预后热休克蛋白70的表达 |
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| 引用本文： | 江承平,刘福,李毅,王柏强,唐晓蓉,吴碧华,王晓明. 脑缺血再灌注损伤模型大鼠参附注射液干预后热休克蛋白70的表达[J]. 中国组织工程研究与临床康复, 2011, 15(41): 7661-7664. DOI: 10.3969/j.issn.1673-8225.2011.41.015 |
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| 作者姓名： | 江承平 刘福 李毅 王柏强 唐晓蓉 吴碧华 王晓明 |
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| 作者单位： | 1. 川北医学院附属医院药剂科,四川省南充市,637007
2. 川北医学院神经病学研究所,四川省南充市,637000 |
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| 摘 要： | 背景:参附注射液可通过改善微循环,增加组织血氧含量发挥对缺血再灌注损伤的保护作用。目的:观察参附注射液对大鼠脑缺血再灌注损伤后热休克蛋白70表达的影响。方法:将SD大鼠随机分为3组:假手术组、大脑中动脉闭塞缺血再灌注损伤模型组、参附注射液组。结果与结论:应用参附注射液1d后,改善了缺血再灌注大鼠脑部神经细胞的排列,减轻了胞体肿胀,核固缩等现象,应用3d后改善更为明显,胞体结构已较清晰,核固缩、溶解程度显著减轻,胞体肿胀现象明显改善。参附注射液组治疗后1,3d热休克蛋白70表达明显高于假手术组与模型组。提示参附注射液对脑缺血再灌注具有显著的保护作用,其作用可能是通过促进热休克蛋白70的表达来实现的。
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| 关 键 词： | 参附注射液 缺血再灌注损伤 热休克蛋白70 脑 大鼠 |
Heat shock protein 70 expression after Shenfu injection administration in a rat model of cerebral ischemia/reperfusion injury |
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| Jiang Cheng-ping,Liu Fu,Li Yi,Wang Bai-qiang,Tang Xiao-rong,Wu Bi-hua,Wang Xiao-ming. Heat shock protein 70 expression after Shenfu injection administration in a rat model of cerebral ischemia/reperfusion injury[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(41): 7661-7664. DOI: 10.3969/j.issn.1673-8225.2011.41.015 |
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| Authors: | Jiang Cheng-ping Liu Fu Li Yi Wang Bai-qiang Tang Xiao-rong Wu Bi-hua Wang Xiao-ming |
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| Affiliation: | Jiang Cheng-ping1,Liu Fu1,Li Yi1,Wang Bai-qiang1,Tang Xiao-rong1,Wu Bi-hua2,Wang Xiao-ming2 1Department of Pharmacology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637007,Sichuan Province,China,2Neurology Research Institute,North Sichuan Medical College |
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| Abstract: | BACKGROUND:Shenfu injection plays a protective effect on ischemia/reperfusion injury in improving microcirculation and increasing blood oxygen content in tissue.OBJECTIVE:To investigate the effects of Shenfu injection on heat shock protein 70(Hsp70) expression in a rat model of cerebral ischemia/reperfusion injury.METHODS:SD rats were randomly divided into three groups(n=32 for each group):sham-operated,middle cerebral artery occlusion(MCAO),and Shenfu injection.RESULTS AND CONCLUSION:Shenfu injection impro... |
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