| 壳聚糖纳米粒子基因载体的研究现状 |
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| 引用本文： | 李广峰,杨建东. 壳聚糖纳米粒子基因载体的研究现状[J]. 中国组织工程研究与临床康复, 2011, 15(47). DOI: 10.3969/j.issn.1673-8225.2011.47.035 |
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| 作者姓名： | 李广峰 杨建东 |
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| 作者单位： | 扬州大学临床医学院骨科,江苏省扬州市,225001 |
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| 摘 要： | 背景:壳聚糖纳米粒子因其独有特性作为基因载体的研究日益增多.目的:综述了壳聚糖纳米粒子作为基因载体的研究进展,进一步促进基因治疗的效果.方法:应用计算机检索web of science 数据库和中国学术期刊数据库中2000-01/2011-04 关于壳聚糖及其衍生物作为基因载体研究的文章,在标题和摘要中以"chitosan,gene"或 "壳聚糖;基因"为检索词进行检索.选择内容与基因载体和壳聚糖相关的文章,初检得到120 篇文献,根据纳入标准选择31 篇文章进行综述.结果与结论:壳聚糖基因纳米粒子作为非病毒基因述文章的数量、主要结载体将在基因治疗领域中发挥举足轻重的作用,今后壳聚糖转基因体系的研究将更为深入.如何标记、可视跟踪壳聚糖DNA 复合物进入不同细胞的过程,明确其基因转染机制,进一步提高基因转染效率,使其尽快进入基因治疗临床应用是今后研究的主要方向.
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| 关 键 词： | 壳聚糖 基因治疗 载体 制备 改性 |
Research advances of chitosan nanoparticles as genetic carriers |
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| Li Guang-feng,Yang Jian-dong. Research advances of chitosan nanoparticles as genetic carriers[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(47). DOI: 10.3969/j.issn.1673-8225.2011.47.035 |
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| Authors: | Li Guang-feng Yang Jian-dong |
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| Affiliation: | Li Guang-feng,Yang Jian-dong Department of Orthopaedics,Clinical Medical College of Yangzhou University,Yangzhou 225001,Jiangsu Province,China |
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| Abstract: | BACKGROUND: In recent years, studies of chitosan as a genetic carrier multiplied for its own characteristics have been increased gradually. OBJECTIVE: To review the research advances of chitosan nanoparticles as a genetic carrier, and to further improve the effect of gene therapy. METHODS: Web of Science and CNKI databases were searched (2000-01/2011-04) with the key words of chitosan, gene in English and Chinese, respectively. 120 articles related to gene carrier and chitosan were selected firstly, and fin... |
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| 本文献已被 CNKI 万方数据 等数据库收录！ |
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